Police first received a call about the bull at 10:20 a.m., an NYPD spokesperson said.
More than an hour later, police cornered the bull again, delivering more sedation for its final capture.
The bull reportedly escaped from a large group being delivered to a slaughterhouse on Jamaica Avenue.
"It was at least the third loose cow or bull in Queens in the last 14 months", New York'sChannel NBC 4 TV reports.
Although the animal was sedated with darts, it managed to continue evading other attempts to corner it until about 12:30 p.m.
A bull was on the loose in Jamaica, Queens on Tuesday, Feb. 21, 2017. Police said there was no indication as of yet where the cow had originally come from.
Officers trailed after the bull for about two hours, trying to trap it between police vehicles and avoid being injured. A representative of the Skylands Animal Sanctuary in New Jersey was on his way to rescue the bull prior to its death. The cow was renamed Freddie. The body was being sent to a crematorium on Long Island, he said.