The team announced the release of Oher on Thursday afternoon, after Oher failed his physical.
Oher signed a three-year, $21.6 million contract extension with the Panthers last summer.
"The most important thing is his health", Panthers coach Ron Rivera said, according to the team's website.
A couple of other factors could have played a role in Oher's release though.
Michael Oher, a former first-round pick and the focus of the popular sports movie, The Blind Side, is out of a job. "You have to be careful with it", Oher Tweeted after being released. We were not going to force the issue.
It was the second move made by interim general manager Marty Hurney since being hired Wednesday.
Oher started the first three games last season for Carolina before suffering a concussion that kept him out the remainder of the season. "Michael understood and we expressed that to him". Oher's unlikely rise from childhood poverty to the National Football League was told in the 2009 movie "The Blind Side, starring Sandra Bullock".
Before the concussion that ended his 2016 campaign, Oher had started 110 games throughout his career with the Baltimore Ravens and Panthers. He was a member of the Baltimore's Super Bowl XLVII championship team following the 2012 season.
Oher, one of the few players on social media to support former Panthers general manager Dave Gettleman after he was sacked Monday, has a Friday court date in Nashville, Tennessee, after being charged with misdemeanor assault.