Ghana had also previously won the tournament in 2013 when the country hosted it.
Nigeria's home-based Super Eagles lost the 2017 WAFU Cup of Nations trophy to Black Stars of Ghana 4-1 last night.
They finished third on their debut in 2014 in South Africa, but failed to go past the group stage previous year in Rwanda. They were poor in every department of the WAFU Cup final except in the goal area where Ikechukwu Ezenwa did his best to emerge the Best Goal Keeper of the tournament.
Two goals from Stephen Sarfo, a goal each from Kwame Kizito and Winful Cobbinah sealed the victory.
Nigeria hit a consolation goal through Rabiu Ali later in additional time.
The Westerlo FC of Lagos loanee was a surprise inclusion in Coach Salisu Yusuf's squad for the tournament and was impressive for the Home Eagles, helping them record five clean sheets during the tournament only to capitulate 4-1 in the final. Sunday will be a new chapter we have to open and we will do so by trying to beat Nigeria.
Both sides had earlier met in the group stage with Nigeria winning 2-0 to secure qualification into the semi-finals.
Ghana goal scorer, Sarfo continued from where he stopped in the first half as he kept on causing headache for the Nigeria defence.
"To let in four goals in the last game of competition is one of those things in football", he reasoned.
The defender who comically added that despite the fact that Nigeria lost the match that the country's jollof rice is still better than that of Ghana.
"The Super Eagles have become used to winning, from winning the CHAN ticket to conquering Sierra Leone and even Ghana here to reach the final, and we can not stop now".