Pogba injured his hamstring in a Champions League tie against Basel earlier this month and initial reports suggested the France midfielder could be out for 12 weeks. "So until the moment we have Zlatan we can not think about giving rest to our No 9, the same way we give in other positions".
Mourinho, who hailed Lukaku's development since last working with the player during their time at Chelsea, said he must continue leading United's line until Ibrahimovic's return.
United made it two wins in as many games in the Champions League, after triumphing 4-1 in Moscow against CSKA. "I don't want to speak about his progress", the Portuguese manger said when he was asked whether the striker has delivered for the Manchester side since his arrival or not.
"I think every step in his [Lukaku's] career he grabbed it [the opportunity] with both hands".
Manchester United legend and former captain Roy Keane has backed his old to returning to winning ways and once more compete for major honours at home and overseas after witnessing another strong performance to kick off 2017/18.
Like Young, it is believed Blind will be back at Old Trafford next term.
Matic also echoed his manager's words, saying that United had "great players" that could help them win despite the absence of key players.
Since his £75m (€85.3m) move from Everton in the summer, the 24-year-old has hit the ground running, scoring 10 goals in nine games in all competitions.
The Belgian global striker has been an inspiration for both club and country so far this season, scoring 14 goals in 11 games for United and Belgium.
"I'm talking about players like Ronaldo, Messi and Bale".
"The mentality is very important because we played Wednesday night and we arrived in Manchester at 4am, so home 5am".