Elliott will not play Sunday after a second circuit U.S. Court of Appeals denied Elliott's motion for an injunction to block his suspension.
Though Columbus authorities never filed charges, the NFL leveled the ban on Elliott for violating the league's personal conduct policy.
However, the one positive to Thursday's ruling is that he'll now be eligible to return on Christmas Eve in a Week 16 matchup with the Seattle Seahawks and can participate in the postseason if the Cowboys make it.
"This is bigger than a suspension, this is bigger than football", Elliott told reporters.
Elliott can still appeal this decision, and the decision issued on Thursday says the appeal would be heard on an expedited basis.
If Elliott chooses, he can continue fighting the league in court, but the best he can hope for now is regaining the $560,000 in salary he'll miss out on over the next month and a half.
Dallas (5-3), on a three-game winning streak with significant contributions from Elliott, visits defending NFC champion Atlanta (4-4) on Sunday, the Associated Press notes.
The NFLPA has argued a suspension would irreparably harm Elliott's career.
The court's ruling allows the NFL to re-suspend Elliott for six games, per NFL Network's legal analyst Gabe Feldman.
The union immediately appealed Goodell's decision and Elliott has been able to play while the case works its way through the legal system and led to hard feelings between Cowboys owner Jerry Jones and Goodell.
The difference this week is that Elliott, the NFL's second-leading rusher, was with his teammates.