Manchester City extended their winning run in the Premier League to 16 games at the Etihad.
City have scored 52 goals in 17 league games this season, earning praise for their style, while Mourinho's United have been criticised for their approach despite sitting second.
In fact, the former defender turned BT Sport pundit even made it clear he thinks they're favourites to win the Champions League, and many people agree after their kind draw against Basel and their blistering form this season.
"You see him how he runs without the ball, he's a good example for the young players and for our academy, for Phil Foden, for Brahim (Diaz), they know how good Kevin De Bruyne is. I hope they win the Cup as well and if we can play them in the Champions League final that would be good", Pique told The Telegraph.
"I am proud, I don't want to be humble, I am proud with my staff".
Ilkay Gundogan opened the scoring in the 14th minute with a simple header before Raheem Sterling added two late goals to put some gloss on the result, particularly after Gabriel Jesus hit the post from the penalty spot.